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Breast cancer risk increases by 3% for each year older a woman is when she first gives birth, a meta-analysis showed.[1] The association may be limited to ER/PR-positive tumours.[2-4] ER/PR-positive breast cancer risk is 15% higher in women who first gave birth at an older age, compared with those who did so at a younger age, a meta-analysis showed.[4] HER2-positive and triple-negative breast cancers are not associated with age at first birth.[4] Conversely among BRCA1 mutation carriers, breast cancer risk may be lower in those who are older at first birth, meta-analyses have shown;[5,6] among BRCA2 carriers, breast cancer risk is not associated with age at first birth.[5,6] Breast cancer risk increases by 5% for each year younger at menarche (first menstrual period), a meta-analysis has shown.[7] The association is stronger for oestrogen receptor (ER)-positive and progesterone receptor (PR)-positive tumours than for ER- and PR-negative tumours.[2] Breast cancer risk may be higher in women whose breast development started at a younger age, a cohort study indicates.[8] Among BRCA1 mutation carriers too, breast cancer risk may be higher in those who are younger at menarche, a meta-analysis showed; among BRCA2 carriers, breast cancer risk is not associated with age at menarche.[5,6] Breast cancer risk increases by around 3% for each year older at menopause, a meta-analysis has shown.[7] Post-menopausal women (natural menopause or induced by surgery) have a lower risk of breast cancer than pre-menopausal women of the same age and childbearing pattern, a meta-analysis showed.[7] Reproductive organ surgery Breast cancer risk is not associated with tubal sterilisation, a meta-analysis showed.[9] Breast cancer risk is 24-41% lower in women who have hysterectomy and oophorectomy before menopause, compared with women who do not have these surgeries, a pooled analysis and case-control study showed.[10,11] Hysterectomy and oophorectomy after menopause may be associated with increased breast cancer risk if oestrogen therapy is used after the surgery, a pooled analysis showed.[10] Breast cancer risk decreases by 7% with each live birth, meta-analyses have shown.[1,2] Breast cancer risk may not be associated with twin pregnancy, a meta-analysis showed.[12] ER/PR-positive breast cancer risk is 25% lower in women who have had children compared with those who have not, a meta-analysis showed.[4] HER2-positive and triple-negative breast cancer is not associated with parity.[4] The association between parity and breast cancer may vary by tumour types, with the largest risk reduction for mucinous tumours, and a risk increase for medullary tumours, a cohort study indicates.[13] Conversely among BRCA1/2 mutation carriers, breast cancer risk is not associated with parity, one meta-analysis showed,[5] though another showed a decreased risk with higher parity.[6] International Agency for Research on Cancer (IARC) classifies the role of this risk factor in cancer development.[1] An estimated 1% of female breast cancers in the UK are linked to oral contraceptives (OCs); because breast cancer risk is generally low in the OC-using population (typically younger women), OC-related risk contributes a relatively small number of additional cases.[2] OCs contain synthetic sex hormones, which may explain the link between OC use and breast cancer risk.

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